Autoantibodies to Neurotrophic Receptors TrkA, TrkB and TrkC in Patients with Acute Chagas’ Disease
نویسندگان
چکیده
منابع مشابه
The neurotrophin receptors TrkA and TrkC but not TrkB cause neuronal death
Biozentrum, University of Basel, CH-4056 Basel, Switzerland; Helmholtz Zentrum München, Institute of Stem Cell Research, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany; Instituto Cajal, CSIC, Avda Dr Arce 37, E-28002 Madrid, Spain; Neurodegeneration Department, Neuroscience Research, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland 5 present address: Novartis Pha...
متن کاملAmitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity.
Neurotrophins, the cognate ligands for the Trk receptors, are homodimers and induce Trk dimerization through a symmetric bivalent mechanism. We report here that amitriptyline, an antidepressant drug, directly binds TrkA and TrkB and triggers their dimerization and activation. Amitriptyline, but not any other tricyclic or selective serotonin reuptake inhibitor antidepressants, promotes TrkA auto...
متن کاملExpression of trkA, trkB, and trkC in injured and regenerating retinal ganglion cells of adult rats.
PURPOSE To investigate changes in percentage of tyrosine kinase (trk)A-, trkB-, and trkC-immunopositive ((+)) retinal ganglion cells (RGCs) at various times after optic nerve (ON) axotomy; the proportion of RGCs regenerating axons into peripheral nerve (PN) grafts that are trkA(+), trkB(+), and trkC(+); whether intravitreal PN-ON implants affect trk immunoreactivity; and the levels of trk mRNAs...
متن کاملExpression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC.
Animals lacking neurotrophin-3 (NT-3) are born with deficits in almost all sensory ganglia. Among these, the trigeminal ganglion is missing 70% of the normal number of neurons, a deficit which develops during the major period of neurogenesis between embryonic stages (E) 10.5 and E13.5. In order to identify the mechanisms for this deficit, we used antisera specific for TrkA, TrkB, and TrkC to ch...
متن کاملTrypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC.
Trypanosoma cruzi, the agent of Chagas' disease, promotes neuron survival through receptor tyrosine kinase TrkA and glycosylphosphatidylinositol-anchored glial cell-derived family ligand receptors (GFRalpha). However, these receptors are expressed by only a subset of neurons and at low levels or not at all in glial cells. Thus, T. cruzi might exploit an additional neurotrophic receptor(s) to ma...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2010
ISSN: 0300-9475,1365-3083
DOI: 10.1111/j.1365-3083.2009.02364.x